Twelve people were killed when several missiles were fired by a suspected US drone targeting militants in north-west Pakistan, security officials said.
The pre-dawn attack - the third in less than 24 hours - took place in Dargah Mandi village near Miranshah, the main town in North Waziristan province.
The attack was directed at Pakistan-based Haqqani group, officials said.
It is the 12th drone strike this month in the region, a stronghold of the Taliban and al-Qaeda.
The attacks have killed hundreds of people since January 2009 and fuelled anti-American sentiment in the country.
Reports said the drones fired at least 10 missiles. Many people were reported injured in the attack.
Residents said there was panic in the village as the drones were heard just before dawn.
"As the US drones came over the village people started shouting and running here and there, shouting - run, drones have come," news agency AFP quoted a local tribesman as saying.
အျပည့္အစုံဖတ္မယ္.. ဒန္.. ဒန္.. ဒန္
★ ★ ★ ★ ★ငါတုိ႔ျမန္မာ့ေျမတြင္ မြတ္ဆလင္ေတြလုိ အေဖက သမီး၊ သားက အေမ၊ အစ္ကိုက ညီမ၊ တူက အေဒၚ၊ ေျမးက အဖြားကုိ မုဒိမ္းက်င့္တဲ့ အျဖစ္မ်ဳိးလုံး၀မရွိ။ တရုတ္လုိလည္း ကေလးအရင္းကုိ မိန္းခေလးျဖစ္လုိ႔ ေမြးခန္းထဲမွာ သတ္ျဖတ္ျခင္းမ်ဳိးငါတုိ႔မွာ မရွိ။ အေနာက္ဖက္လုိလည္း ကာကြယ္ေဆးမွာ အဆိပ္ခတ္တာမ်ဳိးလည္းမရွိ။ နအဖႏွင့္ ဒီမုိသမားေတြအခ်င္းခ်င္း ေစာက္တင္းေျပာတာေတြ ၾကားဖန္မ်ားလုိ႔ ၊ မၾကီးမငယ္ရန္ျဖစ္တာေတြ ျမင္ဖန္မ်ားလုိ႔သာ ျမန္မာျဖစ္ရတာကုိ ဂုဏ္ငယ္ေနျခင္းျဖစ္၏ ☼ ႏွစ္သစ္မွာ ျမန္မာျဖစ္ရတာဂုဏ္ယူတတ္ပါေစ။ ☼ အမ်ဳိးဘာသာ သာသနာအတြက္ ဂုဏ္ယူတတ္ပါေစ။☼ ယုတ္ညံ့သည့္မြတ္ဆလင္၀ါဒ အျမစ္ျဖဳတ္ေရးမွာ အုတ္တစ္ခ်ပ္သဲတစ္ပြင့္ျဖစ္လာပါေစ။